Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5734591

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Pharmaceutical Effect Mean Inhibitory Effect: ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric—SPA Inhibitor IC50 Mean IC50 (nM) was determined for the compounds of examples 1-14.
ChEMBL ↗
36
Total Activities
12
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

IBAT inhibitors for the treatment of liver diseases
(2019)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 9.58 9.96
kon 12 - -
k_off 12 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5778792 — — 3 9.96
CHEMBL5980362 — — 3 9.89
CHEMBL5740083 — — 3 9.82
CHEMBL4297588 ODEVIXIBAT 4.0 3 9.80
CHEMBL5868054 — — 3 9.74
CHEMBL5776872 — — 3 9.70
CHEMBL5808613 — — 3 9.52
CHEMBL6016158 — — 3 9.46
CHEMBL6045294 — — 3 9.44
CHEMBL6002118 — — 3 9.41
CHEMBL5906168 — — 3 9.35
CHEMBL3039515 ELOBIXIBAT 3.0 3 8.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5778792 — IC50 = 0.11 nM 9.96
CHEMBL5980362 — IC50 = 0.13 nM 9.89
CHEMBL5740083 — IC50 = 0.15 nM 9.82
CHEMBL4297588 ODEVIXIBAT IC50 = 0.16 nM 9.80
CHEMBL5868054 — IC50 = 0.18 nM 9.74
CHEMBL5776872 — IC50 = 0.2 nM 9.70
CHEMBL5808613 — IC50 = 0.3 nM 9.52
CHEMBL6016158 — IC50 = 0.35 nM 9.46
CHEMBL6045294 — IC50 = 0.36 nM 9.44
CHEMBL6002118 — IC50 = 0.39 nM 9.41
CHEMBL5906168 — IC50 = 0.45 nM 9.35
CHEMBL3039515 ELOBIXIBAT IC50 = 1.2 nM 8.92
CHEMBL6045294 — k_off = - s-1 -
CHEMBL6045294 — kon = - — -
CHEMBL4297588 ODEVIXIBAT k_off = - s-1 -
CHEMBL4297588 ODEVIXIBAT kon = - — -
CHEMBL6016158 — k_off = - s-1 -
CHEMBL6016158 — kon = - — -
CHEMBL5868054 — k_off = - s-1 -
CHEMBL5868054 — kon = - — -
CHEMBL6002118 — k_off = - s-1 -
CHEMBL6002118 — kon = - — -
CHEMBL5906168 — k_off = - s-1 -
CHEMBL5906168 — kon = - — -
CHEMBL5778792 — kon = - — -
CHEMBL5778792 — k_off = - s-1 -
CHEMBL3039515 ELOBIXIBAT k_off = - s-1 -
CHEMBL5776872 — kon = - — -
CHEMBL5776872 — k_off = - s-1 -
CHEMBL3039515 ELOBIXIBAT kon = - — -
CHEMBL5740083 — kon = - — -
CHEMBL5980362 — k_off = - s-1 -
CHEMBL5740083 — k_off = - s-1 -
CHEMBL5980362 — kon = - — -
CHEMBL5808613 — k_off = - s-1 -
CHEMBL5808613 — kon = - — -