Assay Detail
Binding
CHEMBL5735934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
LOX Activity in Cysts Assay: To produce MDCK cysts, cells were cultured on Matrigel (Corning) with 2% Matrigel supplemented in DMEM with 10% FBS. Cysts were allowed to form for 10 days before subsequent studies.
12
Total Activities
4
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.16 | 6.72 |
| kon | 4 | - | - |
| k_off | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444163 | — | — | 3 | 6.72 |
| CHEMBL4596464 | — | — | 3 | 6.16 |
| CHEMBL4441173 | — | — | 3 | 5.60 |
| CHEMBL4528500 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444163 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4596464 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4441173 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4441173 | — | kon | = | - | — | - |
| CHEMBL4441173 | — | k_off | = | - | s-1 | - |
| CHEMBL4528500 | — | IC50 | < | 180.0 | nM | - |
| CHEMBL4528500 | — | kon | = | - | — | - |
| CHEMBL4528500 | — | k_off | = | - | s-1 | - |
| CHEMBL4444163 | — | kon | = | - | — | - |
| CHEMBL4444163 | — | k_off | = | - | s-1 | - |
| CHEMBL4596464 | — | kon | = | - | — | - |
| CHEMBL4596464 | — | k_off | = | - | s-1 | - |