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Assay Detail

CHEMBL5736392

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Fluorescence Polarization Assay: Binding to PDEδ was validated and quantified by means of a displacement assay employing a fluorescent-tagged analog of the HMG-CoA reductase inhibitor Atorvastatin (Lipitor®) which has previously been shown to also bind to PDEδ. The KD values were determined by the Fluorescence polarization competition binding assay previously developed by the inventors (Nature 2013, 497, 638).
300
Total Activities
99
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Benzene disulfonamide for the treatment of cancer
(2021)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 100 6.98 7.80
kon 100 - -
k_off 100 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5923770 3 7.80
CHEMBL5783532 3 7.80
CHEMBL5874732 3 7.80
CHEMBL5934707 3 7.80
CHEMBL5985909 3 7.80
CHEMBL5776806 3 7.80
CHEMBL6037908 3 7.80
CHEMBL4472979 3 7.80
CHEMBL6035911 3 7.80
CHEMBL5793650 3 7.80
CHEMBL5906489 3 7.80
CHEMBL5926653 3 7.80
CHEMBL5761882 3 7.80
CHEMBL5836303 3 7.80
CHEMBL5883143 3 7.80
CHEMBL5947464 3 7.80
CHEMBL5835926 3 7.80
CHEMBL5820694 3 7.80
CHEMBL6052329 3 7.80
CHEMBL5810306 3 7.80
CHEMBL5888018 3 7.80
CHEMBL5852089 3 7.80
CHEMBL5898748 3 7.80
CHEMBL5817462 3 7.80
CHEMBL5833552 3 7.80
CHEMBL5834014 3 7.80
CHEMBL5998458 3 7.80
CHEMBL6046990 3 7.19
CHEMBL5999826 3 7.19
CHEMBL5827517 3 7.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5817462 Kd = 16.0 nM 7.80
CHEMBL5898748 Kd = 16.0 nM 7.80
CHEMBL6052329 Kd = 16.0 nM 7.80
CHEMBL6037908 Kd = 16.0 nM 7.80
CHEMBL5906489 Kd = 16.0 nM 7.80
CHEMBL5985909 Kd = 16.0 nM 7.80
CHEMBL5883143 Kd = 16.0 nM 7.80
CHEMBL5934707 Kd = 16.0 nM 7.80
CHEMBL5926653 Kd = 16.0 nM 7.80
CHEMBL5947464 Kd = 16.0 nM 7.80
CHEMBL5776806 Kd = 16.0 nM 7.80
CHEMBL5793650 Kd = 16.0 nM 7.80
CHEMBL4472979 Kd = 16.0 nM 7.80
CHEMBL5998458 Kd = 16.0 nM 7.80
CHEMBL5923770 Kd = 16.0 nM 7.80
CHEMBL5783532 Kd = 16.0 nM 7.80
CHEMBL5761882 Kd = 16.0 nM 7.80
CHEMBL5810306 Kd = 16.0 nM 7.80
CHEMBL5833552 Kd = 16.0 nM 7.80
CHEMBL5820694 Kd = 16.0 nM 7.80
CHEMBL5836303 Kd = 16.0 nM 7.80
CHEMBL5835926 Kd = 16.0 nM 7.80
CHEMBL6035911 Kd = 16.0 nM 7.80
CHEMBL5852089 Kd = 16.0 nM 7.80
CHEMBL5888018 Kd = 16.0 nM 7.80
CHEMBL5874732 Kd = 16.0 nM 7.80
CHEMBL5834014 Kd = 16.0 nM 7.80
CHEMBL5874448 Kd = 65.0 nM 7.19
CHEMBL5987708 Kd = 65.0 nM 7.19
CHEMBL5885566 Kd = 65.0 nM 7.19
CHEMBL6038525 Kd = 65.0 nM 7.19
CHEMBL5888475 Kd = 65.0 nM 7.19
CHEMBL6050420 Kd = 65.0 nM 7.19
CHEMBL5827517 Kd = 65.0 nM 7.19
CHEMBL5778487 Kd = 65.0 nM 7.19
CHEMBL5982138 Kd = 65.0 nM 7.19
CHEMBL5933389 Kd = 65.0 nM 7.19
CHEMBL5774651 Kd = 65.0 nM 7.19
CHEMBL6046990 Kd = 65.0 nM 7.19
CHEMBL5874448 Kd = 65.0 nM 7.19
CHEMBL6018117 Kd = 65.0 nM 7.19
CHEMBL5768434 Kd = 65.0 nM 7.19
CHEMBL1561606 Kd = 65.0 nM 7.19
CHEMBL5957621 Kd = 65.0 nM 7.19
CHEMBL6023982 Kd = 65.0 nM 7.19
CHEMBL5821289 Kd = 65.0 nM 7.19
CHEMBL5999826 Kd = 65.0 nM 7.19
CHEMBL5768048 Kd = 65.0 nM 7.19
CHEMBL5850537 Kd = 65.0 nM 7.19
CHEMBL5928962 Kd = 65.0 nM 7.19