Assay Detail
Binding
CHEMBL5736505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
ligand sensing assay (LiSA): As used herein, reference to the activity of an LXR agonist at LXRα and LXRβ refer to the activity as measured using the ligand sensing assay (LiSA) described in Spencer et al. Journal of Medicinal Chemistry 2001, 44, 886-897, incorporated herein by reference.
18
Total Activities
6
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Treatment and diagnosis of melanoma
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.91 | 7.70 |
| kon | 6 | - | - |
| k_off | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 3 | 7.70 |
| CHEMBL5775096 | — | — | 3 | 7.13 |
| CHEMBL456237 | LXR-623 | 1.0 | 3 | 6.75 |
| CHEMBL59030 | — | — | 3 | 6.70 |
| CHEMBL3360975 | BMS-779788 | 1.0 | 3 | 6.26 |
| CHEMBL3945199 | BMS-852927 | 1.0 | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5775096 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL456237 | LXR-623 | EC50 | = | 179.0 | nM | 6.75 |
| CHEMBL59030 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3360975 | BMS-779788 | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL59030 | — | kon | = | - | — | - |
| CHEMBL59030 | — | k_off | = | - | s-1 | - |
| CHEMBL5775096 | — | kon | = | - | — | - |
| CHEMBL5775096 | — | k_off | = | - | s-1 | - |
| CHEMBL62136 | T091317 | kon | = | - | — | - |
| CHEMBL62136 | T091317 | k_off | = | - | s-1 | - |
| CHEMBL456237 | LXR-623 | kon | = | - | — | - |
| CHEMBL456237 | LXR-623 | k_off | = | - | s-1 | - |
| CHEMBL3945199 | BMS-852927 | EC50 | < | 100.0 | nM | - |
| CHEMBL3945199 | BMS-852927 | kon | = | - | — | - |
| CHEMBL3945199 | BMS-852927 | k_off | = | - | s-1 | - |
| CHEMBL3360975 | BMS-779788 | kon | = | - | — | - |
| CHEMBL3360975 | BMS-779788 | k_off | = | - | s-1 | - |