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Assay Detail

CHEMBL5736767

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
LOXL2 Enzyme Activity Assay (20 hours): 10. Incubate for 20 hrs at room temp on a plate shaker, protected from light.
ChEMBL ↗
129
Total Activities
42
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Lysyl oxidase homolog 2 (CHEMBL3714029) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
(2021)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 6.76 7.55
kon 43 - -
k_off 43 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4515085 — — 3 7.55
CHEMBL4597759 — — 3 7.35
CHEMBL4526964 — — 6 7.25
CHEMBL4594701 — — 3 7.25
CHEMBL4450748 — — 3 7.24
CHEMBL4447452 — — 3 7.22
CHEMBL4564074 — — 3 7.19
CHEMBL4596100 — — 3 7.17
CHEMBL4597447 — — 3 7.16
CHEMBL4597285 — — 3 7.16
CHEMBL4596936 — — 3 7.13
CHEMBL4525828 — — 3 7.13
CHEMBL4470882 — — 3 7.09
CHEMBL4457629 — — 3 7.05
CHEMBL4568508 — — 3 7.05
CHEMBL4598392 — — 3 7.00
CHEMBL4462499 — — 3 6.96
CHEMBL4598393 — — 3 6.96
CHEMBL4444163 — — 3 6.89
CHEMBL4597760 — — 3 6.85
CHEMBL4596704 — — 3 6.82
CHEMBL4475714 — — 3 6.77
CHEMBL4564517 — — 3 6.72
CHEMBL4443558 — — 3 6.70
CHEMBL4595979 — — 3 6.70
CHEMBL4597162 — — 3 6.70
CHEMBL4595035 — — 3 6.66
CHEMBL4456682 — — 3 6.64
CHEMBL4596101 — — 3 6.64
CHEMBL4441173 — — 3 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4515085 — IC50 = 28.0 nM 7.55
CHEMBL4597759 — IC50 = 45.0 nM 7.35
CHEMBL4526964 — IC50 = 56.0 nM 7.25
CHEMBL4594701 — IC50 = 56.0 nM 7.25
CHEMBL4450748 — IC50 = 58.0 nM 7.24
CHEMBL4447452 — IC50 = 60.0 nM 7.22
CHEMBL4564074 — IC50 = 65.0 nM 7.19
CHEMBL4596100 — IC50 = 68.0 nM 7.17
CHEMBL4597447 — IC50 = 70.0 nM 7.16
CHEMBL4597285 — IC50 = 70.0 nM 7.16
CHEMBL4596936 — IC50 = 74.0 nM 7.13
CHEMBL4525828 — IC50 = 74.0 nM 7.13
CHEMBL4470882 — IC50 = 82.0 nM 7.09
CHEMBL4568508 — IC50 = 90.0 nM 7.05
CHEMBL4457629 — IC50 = 90.0 nM 7.05
CHEMBL4598392 — IC50 = 100.0 nM 7.00
CHEMBL4462499 — IC50 = 110.0 nM 6.96
CHEMBL4598393 — IC50 = 110.0 nM 6.96
CHEMBL4444163 — IC50 = 130.0 nM 6.89
CHEMBL4597760 — IC50 = 140.0 nM 6.85
CHEMBL4596704 — IC50 = 150.0 nM 6.82
CHEMBL4475714 — IC50 = 170.0 nM 6.77
CHEMBL4564517 — IC50 = 190.0 nM 6.72
CHEMBL4597162 — IC50 = 200.0 nM 6.70
CHEMBL4443558 — IC50 = 200.0 nM 6.70
CHEMBL4595979 — IC50 = 200.0 nM 6.70
CHEMBL4595035 — IC50 = 220.0 nM 6.66
CHEMBL4596101 — IC50 = 230.0 nM 6.64
CHEMBL4456682 — IC50 = 230.0 nM 6.64
CHEMBL4441173 — IC50 = 260.0 nM 6.58
CHEMBL4586111 — IC50 = 260.0 nM 6.58
CHEMBL4458145 — IC50 = 270.0 nM 6.57
CHEMBL4596102 — IC50 = 370.0 nM 6.43
CHEMBL4598164 — IC50 = 380.0 nM 6.42
CHEMBL4526964 — IC50 = 400.0 nM 6.40
CHEMBL4598267 — IC50 = 420.0 nM 6.38
CHEMBL4555200 — IC50 = 500.0 nM 6.30
CHEMBL4597758 — IC50 = 640.0 nM 6.19
CHEMBL4456211 — IC50 = 680.0 nM 6.17
CHEMBL5955317 — IC50 = 1000.0 nM 6.00
CHEMBL4595071 — IC50 = 1000.0 nM 6.00
CHEMBL4597412 — IC50 = 1300.0 nM 5.89
CHEMBL4521045 — IC50 = 2400.0 nM 5.62
CHEMBL4447452 — k_off = - s-1 -
CHEMBL4447452 — kon = - — -
CHEMBL4598267 — k_off = - s-1 -
CHEMBL4598393 — k_off = - s-1 -
CHEMBL4470882 — kon = - — -
CHEMBL4594701 — k_off = - s-1 -
CHEMBL4598267 — kon = - — -