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Assay Detail

CHEMBL5736772

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
LOXL2 Enzyme Activity Assay (i hour): 10. Incubate for 1 hr at room temp on a plate shaker, protected from light.
ChEMBL ↗
141
Total Activities
47
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Lysyl oxidase homolog 2 (CHEMBL3714029) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
(2021)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 47 6.53 7.19
kon 47 - -
k_off 47 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4595733 — — 3 7.19
CHEMBL4598011 — — 3 7.18
CHEMBL4595501 — — 3 7.14
CHEMBL4597644 — — 3 7.13
CHEMBL4597645 — — 3 7.11
CHEMBL4597413 — — 3 7.10
CHEMBL4595156 — — 3 7.09
CHEMBL4460845 — — 3 7.07
CHEMBL4595851 — — 3 7.05
CHEMBL4594920 — — 3 7.03
CHEMBL4596103 — — 3 7.02
CHEMBL4598010 — — 3 6.92
CHEMBL4598292 — — 3 6.85
CHEMBL4545533 — — 3 6.85
CHEMBL4597285 — — 3 6.82
CHEMBL4594821 — — 3 6.82
CHEMBL4596012 — — 3 6.77
CHEMBL4468424 — — 3 6.77
CHEMBL4597053 — — 3 6.75
CHEMBL4596814 — — 3 6.75
CHEMBL4596349 — — 3 6.70
CHEMBL4597414 — — 3 6.66
CHEMBL4596464 — — 3 6.62
CHEMBL4595972 — — 3 6.62
CHEMBL4598012 — — 3 6.58
CHEMBL4457668 — — 3 6.58
CHEMBL4528500 — — 3 6.58
CHEMBL4594702 — — 3 6.55
CHEMBL4596704 — — 3 6.55
CHEMBL4597760 — — 3 6.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4595733 — IC50 = 64.0 nM 7.19
CHEMBL4598011 — IC50 = 66.0 nM 7.18
CHEMBL4595501 — IC50 = 72.0 nM 7.14
CHEMBL4597644 — IC50 = 74.0 nM 7.13
CHEMBL4597645 — IC50 = 77.0 nM 7.11
CHEMBL4597413 — IC50 = 79.0 nM 7.10
CHEMBL4595156 — IC50 = 82.0 nM 7.09
CHEMBL4460845 — IC50 = 85.0 nM 7.07
CHEMBL4595851 — IC50 = 89.0 nM 7.05
CHEMBL4594920 — IC50 = 94.0 nM 7.03
CHEMBL4596103 — IC50 = 96.0 nM 7.02
CHEMBL4598010 — IC50 = 120.0 nM 6.92
CHEMBL4598292 — IC50 = 140.0 nM 6.85
CHEMBL4545533 — IC50 = 140.0 nM 6.85
CHEMBL4597285 — IC50 = 150.0 nM 6.82
CHEMBL4594821 — IC50 = 150.0 nM 6.82
CHEMBL4468424 — IC50 = 170.0 nM 6.77
CHEMBL4596012 — IC50 = 170.0 nM 6.77
CHEMBL4596814 — IC50 = 180.0 nM 6.75
CHEMBL4597053 — IC50 = 180.0 nM 6.75
CHEMBL4596349 — IC50 = 200.0 nM 6.70
CHEMBL4597414 — IC50 = 220.0 nM 6.66
CHEMBL4595972 — IC50 = 240.0 nM 6.62
CHEMBL4596464 — IC50 = 240.0 nM 6.62
CHEMBL4457668 — IC50 = 260.0 nM 6.58
CHEMBL4528500 — IC50 = 260.0 nM 6.58
CHEMBL4598012 — IC50 = 260.0 nM 6.58
CHEMBL4596704 — IC50 = 280.0 nM 6.55
CHEMBL4594702 — IC50 = 280.0 nM 6.55
CHEMBL4597760 — IC50 = 290.0 nM 6.54
CHEMBL4442153 — IC50 = 310.0 nM 6.51
CHEMBL4597761 — IC50 = 310.0 nM 6.51
CHEMBL4463882 — IC50 = 320.0 nM 6.50
CHEMBL4594808 — IC50 = 410.0 nM 6.39
CHEMBL4552697 — IC50 = 460.0 nM 6.34
CHEMBL4596134 — IC50 = 480.0 nM 6.32
CHEMBL4598137 — IC50 = 560.0 nM 6.25
CHEMBL4594921 — IC50 = 800.0 nM 6.10
CHEMBL4597286 — IC50 = 1100.0 nM 5.96
CHEMBL4597665 — IC50 = 1200.0 nM 5.92
CHEMBL4475714 — IC50 = 1260.0 nM 5.90
CHEMBL4596728 — IC50 = 1600.0 nM 5.80
CHEMBL4463323 — IC50 = 1800.0 nM 5.75
CHEMBL4596227 — IC50 = 1900.0 nM 5.72
CHEMBL4595171 — IC50 = 1900.0 nM 5.72
CHEMBL4596705 — IC50 = 5000.0 nM 5.30
CHEMBL4595272 — IC50 = 19000.0 nM 4.72
CHEMBL4598012 — kon = - — -
CHEMBL4595171 — kon = - — -
CHEMBL4595972 — k_off = - s-1 -