Assay Detail
Binding
CHEMBL5737474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PI3Kdelta Inhibition Assay: The IC50s obtained by the method of Assay A at 1 mM ATP as described in the US Patent Publications.
33
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrrolopyrimidine derivatives as TAM inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.97 | 7.12 |
| kon | 11 | - | - |
| k_off | 11 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4576207 | — | — | 3 | 7.12 |
| CHEMBL6026135 | — | — | 12 | 6.90 |
| CHEMBL5775827 | — | — | 3 | - |
| CHEMBL2216863 | DEZAPELISIB | 2.0 | 3 | - |
| CHEMBL5776309 | — | — | 3 | - |
| CHEMBL5779126 | — | — | 3 | - |
| CHEMBL5773238 | — | — | 3 | - |
| CHEMBL2216867 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4576207 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL6026135 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL6026135 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL5775827 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL5775827 | — | kon | = | - | — | - |
| CHEMBL5773238 | — | k_off | = | - | s-1 | - |
| CHEMBL5773238 | — | kon | = | - | — | - |
| CHEMBL5773238 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL5779126 | — | k_off | = | - | s-1 | - |
| CHEMBL5779126 | — | kon | = | - | — | - |
| CHEMBL5779126 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL5776309 | — | k_off | = | - | s-1 | - |
| CHEMBL5776309 | — | kon | = | - | — | - |
| CHEMBL5776309 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL2216863 | DEZAPELISIB | k_off | = | - | s-1 | - |
| CHEMBL2216863 | DEZAPELISIB | kon | = | - | — | - |
| CHEMBL2216863 | DEZAPELISIB | IC50 | < | 50.0 | nM | - |
| CHEMBL5775827 | — | k_off | = | - | s-1 | - |
| CHEMBL6026135 | — | k_off | = | - | s-1 | - |
| CHEMBL4576207 | — | k_off | = | - | s-1 | - |
| CHEMBL4576207 | — | kon | = | - | — | - |
| CHEMBL2216867 | — | k_off | = | - | s-1 | - |
| CHEMBL2216867 | — | kon | = | - | — | - |
| CHEMBL2216867 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL6026135 | — | k_off | = | - | s-1 | - |
| CHEMBL6026135 | — | kon | = | - | — | - |
| CHEMBL6026135 | — | k_off | = | - | s-1 | - |
| CHEMBL6026135 | — | kon | = | - | — | - |
| CHEMBL6026135 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL6026135 | — | k_off | = | - | s-1 | - |
| CHEMBL6026135 | — | kon | = | - | — | - |
| CHEMBL6026135 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL6026135 | — | kon | = | - | — | - |