Assay Detail
Binding
CHEMBL5737525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding Assay: ADRB2 IC50 from binding assay(nM), Determined using the Tag-lite Adrenoceptor Beta2 receptor ligand binding assay.
24
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
G protein-coupled receptor kinase 3 (CHEMBL1075166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Adrenergic receptor modulating compounds and methods of using the same
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 10.11 | 10.72 |
| kon | 8 | - | - |
| k_off | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5954552 | — | — | 3 | 10.72 |
| CHEMBL5946696 | — | — | 3 | 10.62 |
| CHEMBL5782704 | — | — | 3 | 10.32 |
| CHEMBL6021679 | — | — | 3 | 10.19 |
| CHEMBL5748424 | — | — | 3 | 9.84 |
| CHEMBL6028513 | — | — | 3 | 9.64 |
| CHEMBL6053158 | — | — | 3 | 9.42 |
| CHEMBL5956027 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5954552 | — | IC50 | = | 0.019 | nM | 10.72 |
| CHEMBL5946696 | — | IC50 | = | 0.024 | nM | 10.62 |
| CHEMBL5782704 | — | IC50 | = | 0.048 | nM | 10.32 |
| CHEMBL6021679 | — | IC50 | = | 0.065 | nM | 10.19 |
| CHEMBL5748424 | — | IC50 | = | 0.144 | nM | 9.84 |
| CHEMBL6028513 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL6053158 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL5956027 | — | kon | = | - | — | - |
| CHEMBL5956027 | — | k_off | = | - | s-1 | - |
| CHEMBL5782704 | — | kon | = | - | — | - |
| CHEMBL5782704 | — | k_off | = | - | s-1 | - |
| CHEMBL5954552 | — | kon | = | - | — | - |
| CHEMBL5954552 | — | k_off | = | - | s-1 | - |
| CHEMBL6021679 | — | kon | = | - | — | - |
| CHEMBL6021679 | — | k_off | = | - | s-1 | - |
| CHEMBL6028513 | — | kon | = | - | — | - |
| CHEMBL6028513 | — | k_off | = | - | s-1 | - |
| CHEMBL5946696 | — | kon | = | - | — | - |
| CHEMBL5946696 | — | k_off | = | - | s-1 | - |
| CHEMBL6053158 | — | kon | = | - | — | - |
| CHEMBL6053158 | — | k_off | = | - | s-1 | - |
| CHEMBL5748424 | — | kon | = | - | — | - |
| CHEMBL5956027 | — | IC50 | = | 0.009 | nM | - |
| CHEMBL5748424 | — | k_off | = | - | s-1 | - |