Assay Detail
Binding
CHEMBL5737620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
High Throughput Screening (HTS) Assa: A high throughput screening (HTS) assay and together with NCATS screened over 350,000 compounds in attempt to identify novel GLS inhibitor structures.
27
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutaminase kidney isoform, mitochondrial (CHEMBL2146302) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.85 | 7.10 |
| kon | 9 | - | - |
| k_off | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814265 | — | — | 3 | 7.10 |
| CHEMBL5880857 | — | — | 3 | 7.00 |
| CHEMBL5896863 | — | — | 3 | 7.00 |
| CHEMBL2178396 | — | — | 3 | 5.72 |
| CHEMBL2178393 | — | — | 3 | 5.57 |
| CHEMBL2177757 | — | — | 6 | 5.48 |
| CHEMBL2177744 | — | — | 3 | 5.34 |
| CHEMBL2177758 | — | — | 3 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814265 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5896863 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5880857 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2178396 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2178393 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2177757 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2177757 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2177744 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2177758 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2177757 | — | kon | = | - | — | - |
| CHEMBL2177757 | — | k_off | = | - | s-1 | - |
| CHEMBL2178393 | — | kon | = | - | — | - |
| CHEMBL2178393 | — | k_off | = | - | s-1 | - |
| CHEMBL2177758 | — | kon | = | - | — | - |
| CHEMBL2177758 | — | k_off | = | - | s-1 | - |
| CHEMBL2178396 | — | kon | = | - | — | - |
| CHEMBL2178396 | — | k_off | = | - | s-1 | - |
| CHEMBL2177744 | — | k_off | = | - | s-1 | - |
| CHEMBL2177757 | — | kon | = | - | — | - |
| CHEMBL5896863 | — | k_off | = | - | s-1 | - |
| CHEMBL5896863 | — | kon | = | - | — | - |
| CHEMBL5880857 | — | k_off | = | - | s-1 | - |
| CHEMBL5880857 | — | kon | = | - | — | - |
| CHEMBL3814265 | — | k_off | = | - | s-1 | - |
| CHEMBL3814265 | — | kon | = | - | — | - |
| CHEMBL2177744 | — | kon | = | - | — | - |
| CHEMBL2177757 | — | k_off | = | - | s-1 | - |