Assay Detail
Binding
CHEMBL5737693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay.
30
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
HDAC6 inhibitors and imaging agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.71 | 7.28 |
| kon | 10 | - | - |
| k_off | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5934316 | — | — | 3 | 7.28 |
| CHEMBL185013 | — | — | 3 | 5.42 |
| CHEMBL4165724 | — | — | 9 | 5.28 |
| CHEMBL5796974 | — | — | 3 | - |
| CHEMBL5752411 | — | — | 3 | - |
| CHEMBL2018302 | TUBASTATIN A | — | 3 | - |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 3 | - |
| CHEMBL235191 | TACEDINALINE | 3.0 | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5934316 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL185013 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4165724 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4165724 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4165724 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5752411 | — | k_off | = | - | s-1 | - |
| CHEMBL4165724 | — | kon | = | - | — | - |
| CHEMBL5752411 | — | kon | = | - | — | - |
| CHEMBL5752411 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5796974 | — | k_off | = | - | s-1 | - |
| CHEMBL5796974 | — | kon | = | - | — | - |
| CHEMBL5796974 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4165724 | — | k_off | = | - | s-1 | - |
| CHEMBL4165724 | — | kon | = | - | — | - |
| CHEMBL185013 | — | k_off | = | - | s-1 | - |
| CHEMBL185013 | — | kon | = | - | — | - |
| CHEMBL4165724 | — | k_off | = | - | s-1 | - |
| CHEMBL5934316 | — | kon | = | - | — | - |
| CHEMBL4165724 | — | kon | = | - | — | - |
| CHEMBL235191 | TACEDINALINE | k_off | = | - | s-1 | - |
| CHEMBL235191 | TACEDINALINE | kon | = | - | — | - |
| CHEMBL235191 | TACEDINALINE | IC50 | > | 33.0 | nM | - |
| CHEMBL2364628 | RICOLINOSTAT | k_off | = | - | s-1 | - |
| CHEMBL2364628 | RICOLINOSTAT | kon | = | - | — | - |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | > | 1000.0 | nM | - |
| CHEMBL2018302 | TUBASTATIN A | k_off | = | - | s-1 | - |
| CHEMBL2018302 | TUBASTATIN A | kon | = | - | — | - |
| CHEMBL2018302 | TUBASTATIN A | IC50 | > | 30.0 | nM | - |
| CHEMBL4165724 | — | k_off | = | - | s-1 | - |
| CHEMBL5934316 | — | k_off | = | - | s-1 | - |