Assay Detail
Binding
CHEMBL5737829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Biochemical Assay: Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 micromolar (μM) EDTA and 0.01% TWEEN-20, final concentration, was used as the assay buffer. The LDHA reagent was 2 nanomolar (nM) Human LDHA (Meridian Life Science, Inc., Memphis, Tenn.), final concentration, in assay buffer. The substrate reagent was 0.06 mM NADH and 0.2 mM sodium pyruvate, final concentration, in assay buffer. The resazurin/diaphorase coupling reagent was 0.037 mM resazurin and 0.133 milligrams per milliliter (mg/mL) diaphorase, final concentration, in assay buffer.
1566
Total Activities
510
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 522 | 5.11 | 6.26 |
| kon | 522 | - | - |
| k_off | 522 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4066429 | — | — | 3 | 6.26 |
| CHEMBL5906632 | — | — | 3 | 6.26 |
| CHEMBL5817226 | — | — | 3 | 6.26 |
| CHEMBL5756621 | — | — | 3 | 6.26 |
| CHEMBL5927493 | — | — | 3 | 6.26 |
| CHEMBL5747101 | — | — | 3 | 6.26 |
| CHEMBL5908466 | — | — | 3 | 6.26 |
| CHEMBL6053543 | — | — | 3 | 6.26 |
| CHEMBL5914170 | — | — | 3 | 6.26 |
| CHEMBL5821897 | — | — | 3 | 6.26 |
| CHEMBL5970507 | — | — | 3 | 6.26 |
| CHEMBL5824084 | — | — | 3 | 6.26 |
| CHEMBL5762971 | — | — | 3 | 6.26 |
| CHEMBL5861592 | — | — | 3 | 6.26 |
| CHEMBL5891480 | — | — | 3 | 6.26 |
| CHEMBL5967853 | — | — | 3 | 6.26 |
| CHEMBL4089051 | — | — | 3 | 6.26 |
| CHEMBL6022710 | — | — | 3 | 6.26 |
| CHEMBL5809745 | — | — | 3 | 6.26 |
| CHEMBL5919037 | — | — | 3 | 6.26 |
| CHEMBL5984996 | — | — | 6 | 6.26 |
| CHEMBL5859497 | — | — | 3 | 6.26 |
| CHEMBL5799758 | — | — | 3 | 6.26 |
| CHEMBL4099443 | — | — | 3 | 6.26 |
| CHEMBL4063125 | — | — | 3 | 6.26 |
| CHEMBL4076973 | — | — | 6 | 6.26 |
| CHEMBL5896240 | — | — | 3 | 6.26 |
| CHEMBL5994969 | — | — | 3 | 6.26 |
| CHEMBL6045830 | — | — | 3 | 6.26 |
| CHEMBL6064754 | — | — | 3 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6023002 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5994969 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5970507 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5889775 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4066429 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5914464 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5838640 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6045830 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4763906 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4790696 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5972786 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5919037 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5799758 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5773388 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5967853 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5821897 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4089051 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4076973 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5914170 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5977606 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6064754 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5762971 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4076973 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6053543 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5809745 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5755709 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5867475 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5958891 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5891389 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5824084 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5818031 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5977404 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5927493 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5890901 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5861613 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4864038 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5974320 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5947721 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5984996 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5756621 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5891480 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5747101 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5841942 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5858423 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6035886 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5817226 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5896240 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5908466 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5834609 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5826765 | — | IC50 | = | 550.0 | nM | 6.26 |