Assay Detail
Binding
CHEMBL5737835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Luminescent Kinase Assay: Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 peptide substrate (KinaseGlo. Notably, both kinases were tested at the same ATP concentration which allows direct comparison of inhibitor potencies due to these enzymes possessing similar Kms for this cofactor.
342
Total Activities
114
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 114 | 7.08 | 9.40 |
| kon | 114 | - | - |
| k_off | 114 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2079170 | — | — | 3 | 9.40 |
| CHEMBL2079317 | — | — | 3 | 9.22 |
| CHEMBL2079169 | — | — | 3 | 9.10 |
| CHEMBL2079168 | — | — | 3 | 8.68 |
| CHEMBL5814019 | — | — | 3 | 8.66 |
| CHEMBL2030553 | — | — | 3 | 8.64 |
| CHEMBL1242384 | — | — | 3 | 8.52 |
| CHEMBL2079230 | — | — | 3 | 8.49 |
| CHEMBL2030554 | — | — | 3 | 8.46 |
| CHEMBL2079167 | — | — | 3 | 8.39 |
| CHEMBL2079139 | — | — | 3 | 8.36 |
| CHEMBL2079231 | — | — | 3 | 8.34 |
| CHEMBL1785020 | — | — | 3 | 8.30 |
| CHEMBL2078800 | — | — | 3 | 8.29 |
| CHEMBL5815380 | — | — | 3 | 8.28 |
| CHEMBL2078805 | — | — | 3 | 8.17 |
| CHEMBL5932426 | — | — | 3 | 8.14 |
| CHEMBL6047545 | — | — | 3 | 8.11 |
| CHEMBL1231372 | — | — | 3 | 8.05 |
| CHEMBL1241489 | — | — | 3 | 8.00 |
| CHEMBL4781903 | — | — | 3 | 7.97 |
| CHEMBL1785021 | — | — | 3 | 7.92 |
| CHEMBL5909447 | — | — | 3 | 7.91 |
| CHEMBL1785012 | — | — | 3 | 7.89 |
| CHEMBL5860895 | — | — | 3 | 7.87 |
| CHEMBL2030556 | — | — | 3 | 7.79 |
| CHEMBL1785018 | — | — | 3 | 7.77 |
| CHEMBL1242754 | — | — | 3 | 7.70 |
| CHEMBL1785017 | — | — | 3 | 7.66 |
| CHEMBL5896441 | — | — | 3 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2079170 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2079317 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2079169 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2079168 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5814019 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2030553 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1242384 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2079230 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2030554 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2079167 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL2079139 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2079231 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1785020 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2078800 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5815380 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2078805 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5932426 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL6047545 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL1231372 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1241489 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4781903 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL1785021 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5909447 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL1785012 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5860895 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL2030556 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL1785018 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1242754 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1785017 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5896441 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL5889864 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL6007727 | — | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL1784965 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2078865 | — | IC50 | = | 49.7 | nM | 7.30 |
| CHEMBL1784969 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1782086 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2079232 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2079214 | — | IC50 | = | 53.2 | nM | 7.27 |
| CHEMBL1784964 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2079138 | — | IC50 | = | 57.3 | nM | 7.24 |
| CHEMBL1231371 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1785014 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2079136 | — | IC50 | = | 70.4 | nM | 7.15 |
| CHEMBL1784972 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2030555 | — | IC50 | = | 83.7 | nM | 7.08 |
| CHEMBL1785015 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL6047364 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5827585 | — | IC50 | = | 93.6 | nM | 7.03 |
| CHEMBL1242660 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1784966 | — | IC50 | = | 103.0 | nM | 6.99 |