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Assay Detail

CHEMBL5738201

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
TBDTR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) Assay: The inhibition constant (Ki) for binding of representative compounds to Bcl-2 protein, as determined by a TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.
ChEMBL ↗
1119
Total Activities
365
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Apoptosis regulator Bcl-2 (CHEMBL4860) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Melt-extruded solid dispersions containing an apoptosis-inducing agent
(2022)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 373 10.02 11.00
kon 373 - -
k_off 373 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5955498 — — 3 11.00
CHEMBL3952489 — — 3 11.00
CHEMBL4228713 A-1211212 — 3 11.00
CHEMBL5911102 — — 3 10.96
CHEMBL3900365 — — 3 10.96
CHEMBL5938241 — — 3 10.92
CHEMBL3902290 — — 3 10.92
CHEMBL3963984 — — 3 10.92
CHEMBL3925316 — — 3 10.89
CHEMBL3901126 — — 3 10.89
CHEMBL3916807 — — 3 10.89
CHEMBL3973960 — — 6 10.89
CHEMBL6047078 — — 3 10.89
CHEMBL3976783 — — 3 10.85
CHEMBL3978223 — — 6 10.85
CHEMBL3901940 — — 6 10.85
CHEMBL3952871 — — 3 10.85
CHEMBL5829019 — — 3 10.85
CHEMBL3955355 — — 3 10.82
CHEMBL3957494 — — 3 10.80
CHEMBL3918493 — — 3 10.80
CHEMBL3907059 — — 3 10.80
CHEMBL3958014 — — 3 10.80
CHEMBL3906596 — — 3 10.80
CHEMBL3970500 — — 3 10.77
CHEMBL3920717 — — 3 10.77
CHEMBL3944117 — — 3 10.77
CHEMBL3936791 — — 3 10.77
CHEMBL3972476 — — 3 10.77
CHEMBL3921409 — — 3 10.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3952489 — Ki = 0.01 nM 11.00
CHEMBL5955498 — Ki = 0.01 nM 11.00
CHEMBL4228713 A-1211212 Ki = 0.01 nM 11.00
CHEMBL5911102 — Ki = 0.011 nM 10.96
CHEMBL3900365 — Ki = 0.011 nM 10.96
CHEMBL5938241 — Ki = 0.012 nM 10.92
CHEMBL3963984 — Ki = 0.012 nM 10.92
CHEMBL3902290 — Ki = 0.012 nM 10.92
CHEMBL6047078 — Ki = 0.013 nM 10.89
CHEMBL3925316 — Ki = 0.013 nM 10.89
CHEMBL3901126 — Ki = 0.013 nM 10.89
CHEMBL3973960 — Ki = 0.013 nM 10.89
CHEMBL3916807 — Ki = 0.013 nM 10.89
CHEMBL3901940 — Ki = 0.014 nM 10.85
CHEMBL3952871 — Ki = 0.014 nM 10.85
CHEMBL5829019 — Ki = 0.014 nM 10.85
CHEMBL3978223 — Ki = 0.014 nM 10.85
CHEMBL3976783 — Ki = 0.014 nM 10.85
CHEMBL3955355 — Ki = 0.015 nM 10.82
CHEMBL3958014 — Ki = 0.016 nM 10.80
CHEMBL3907059 — Ki = 0.016 nM 10.80
CHEMBL3957494 — Ki = 0.016 nM 10.80
CHEMBL3906596 — Ki = 0.016 nM 10.80
CHEMBL3918493 — Ki = 0.016 nM 10.80
CHEMBL3972476 — Ki = 0.017 nM 10.77
CHEMBL3944117 — Ki = 0.017 nM 10.77
CHEMBL3936791 — Ki = 0.017 nM 10.77
CHEMBL3970500 — Ki = 0.017 nM 10.77
CHEMBL3921409 — Ki = 0.017 nM 10.77
CHEMBL3920717 — Ki = 0.017 nM 10.77
CHEMBL3894139 — Ki = 0.018 nM 10.74
CHEMBL5851815 — Ki = 0.018 nM 10.74
CHEMBL3913948 — Ki = 0.019 nM 10.72
CHEMBL3950070 — Ki = 0.021 nM 10.68
CHEMBL3965909 — Ki = 0.021 nM 10.68
CHEMBL3932065 — Ki = 0.021 nM 10.68
CHEMBL3963537 — Ki = 0.022 nM 10.66
CHEMBL3921856 — Ki = 0.022 nM 10.66
CHEMBL3920620 — Ki = 0.023 nM 10.64
CHEMBL3966962 — Ki = 0.023 nM 10.64
CHEMBL3982090 — Ki = 0.023 nM 10.64
CHEMBL3972115 — Ki = 0.023 nM 10.64
CHEMBL3983051 — Ki = 0.024 nM 10.62
CHEMBL3933894 — Ki = 0.024 nM 10.62
CHEMBL3974238 — Ki = 0.024 nM 10.62
CHEMBL3926563 — Ki = 0.026 nM 10.59
CHEMBL3895321 — Ki = 0.026 nM 10.59
CHEMBL5804563 — Ki = 0.029 nM 10.54
CHEMBL3956368 — Ki = 0.029 nM 10.54
CHEMBL3920467 — Ki = 0.03 nM 10.52