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Assay Detail

CHEMBL5738778

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
TBD: TBD
ChEMBL ↗
267
Total Activities
63
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dihydrofolate reductase (CHEMBL202) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Compositions and methods for treating infections
(2022)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 89 5.93 8.39
kon 89 - -
k_off 89 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL119 TRIMETREXATE 4.0 3 8.39
CHEMBL34259 METHOTREXATE 4.0 15 8.37
CHEMBL5941951 — — 3 7.52
CHEMBL3953069 — — 3 7.12
CHEMBL6054471 — — 3 6.89
CHEMBL4544467 — — 6 6.67
CHEMBL5857341 — — 3 6.62
CHEMBL5751279 — — 3 6.53
CHEMBL5985430 — — 3 6.52
CHEMBL5913893 — — 3 6.49
CHEMBL5806347 — — 3 6.43
CHEMBL5936551 — — 3 6.38
CHEMBL5976681 — — 3 6.36
CHEMBL4456834 — — 9 6.31
CHEMBL5796794 — — 3 6.28
CHEMBL4535103 — — 3 6.27
CHEMBL3953119 — — 3 6.16
CHEMBL6034917 — — 3 6.13
CHEMBL4543226 — — 6 6.10
CHEMBL5877082 — — 3 6.10
CHEMBL5941843 — — 3 6.09
CHEMBL5838395 — — 3 6.09
CHEMBL4550110 — — 3 6.08
CHEMBL4468777 FANOTAPRIM 1.0 9 6.04
CHEMBL5759188 — — 6 6.02
CHEMBL5831279 — — 3 5.99
CHEMBL5830010 — — 3 5.99
CHEMBL5891847 — — 3 5.97
CHEMBL4464707 — — 6 5.96
CHEMBL6049272 — — 3 5.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL119 TRIMETREXATE IC50 = 4.07 nM 8.39
CHEMBL34259 METHOTREXATE IC50 = 4.27 nM 8.37
CHEMBL34259 METHOTREXATE IC50 = 5.37 nM 8.27
CHEMBL34259 METHOTREXATE IC50 = 5.37 nM 8.27
CHEMBL34259 METHOTREXATE IC50 = 5.37 nM 8.27
CHEMBL34259 METHOTREXATE IC50 = 5.37 nM 8.27
CHEMBL5941951 — IC50 = 30.2 nM 7.52
CHEMBL3953069 — IC50 = 75.9 nM 7.12
CHEMBL6054471 — IC50 = 129.0 nM 6.89
CHEMBL4544467 — IC50 = 214.0 nM 6.67
CHEMBL5857341 — IC50 = 240.0 nM 6.62
CHEMBL5751279 — IC50 = 295.0 nM 6.53
CHEMBL5985430 — IC50 = 302.0 nM 6.52
CHEMBL5913893 — IC50 = 324.0 nM 6.49
CHEMBL5806347 — IC50 = 372.0 nM 6.43
CHEMBL5936551 — IC50 = 417.0 nM 6.38
CHEMBL5976681 — IC50 = 437.0 nM 6.36
CHEMBL4456834 — IC50 = 490.0 nM 6.31
CHEMBL4456834 — IC50 = 490.0 nM 6.31
CHEMBL5796794 — IC50 = 525.0 nM 6.28
CHEMBL4535103 — IC50 = 537.0 nM 6.27
CHEMBL3953119 — IC50 = 692.0 nM 6.16
CHEMBL6034917 — IC50 = 741.0 nM 6.13
CHEMBL4543226 — IC50 = 794.0 nM 6.10
CHEMBL5877082 — IC50 = 794.0 nM 6.10
CHEMBL5941843 — IC50 = 813.0 nM 6.09
CHEMBL5838395 — IC50 = 813.0 nM 6.09
CHEMBL4550110 — IC50 = 832.0 nM 6.08
CHEMBL4468777 FANOTAPRIM IC50 = 912.0 nM 6.04
CHEMBL4468777 FANOTAPRIM IC50 = 912.0 nM 6.04
CHEMBL5759188 — IC50 = 955.0 nM 6.02
CHEMBL5831279 — IC50 = 1023.0 nM 5.99
CHEMBL5830010 — IC50 = 1023.0 nM 5.99
CHEMBL4543226 — IC50 = 1023.0 nM 5.99
CHEMBL5891847 — IC50 = 1072.0 nM 5.97
CHEMBL4464707 — IC50 = 1096.0 nM 5.96
CHEMBL4456834 — IC50 = 1096.0 nM 5.96
CHEMBL5776717 — IC50 = 1148.0 nM 5.94
CHEMBL6049272 — IC50 = 1148.0 nM 5.94
CHEMBL4468777 FANOTAPRIM IC50 = 1202.0 nM 5.92
CHEMBL4584470 — IC50 = 1288.0 nM 5.89
CHEMBL6014553 — IC50 = 1318.0 nM 5.88
CHEMBL6014553 — IC50 = 1318.0 nM 5.88
CHEMBL4466302 — IC50 = 1318.0 nM 5.88
CHEMBL5883668 — IC50 = 1349.0 nM 5.87
CHEMBL5759188 — IC50 = 1380.0 nM 5.86
CHEMBL5806112 — IC50 = 1413.0 nM 5.85
CHEMBL6001741 — IC50 = 1413.0 nM 5.85
CHEMBL4573445 — IC50 = 1445.0 nM 5.84
CHEMBL5820611 — IC50 = 1585.0 nM 5.80