Assay Detail
Binding
CHEMBL5739474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In Vitro Kinase Activity Assay: Inhibition of various kinases was assayed.
21
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoquinoline-steroid conjugates and uses thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.65 | 7.25 |
| kon | 7 | - | - |
| k_off | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5842146 | — | — | 3 | 7.25 |
| CHEMBL5922741 | — | — | 3 | 6.85 |
| CHEMBL5814965 | — | — | 3 | 6.82 |
| CHEMBL5854473 | — | — | 3 | 6.65 |
| CHEMBL5916377 | — | — | 3 | 6.45 |
| CHEMBL5867395 | — | — | 3 | 6.29 |
| CHEMBL5992697 | — | — | 3 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5842146 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5922741 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5814965 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL5854473 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL5916377 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL5867395 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL5992697 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL5814965 | — | kon | = | - | — | - |
| CHEMBL5814965 | — | k_off | = | - | s-1 | - |
| CHEMBL5854473 | — | kon | = | - | — | - |
| CHEMBL5854473 | — | k_off | = | - | s-1 | - |
| CHEMBL5842146 | — | kon | = | - | — | - |
| CHEMBL5842146 | — | k_off | = | - | s-1 | - |
| CHEMBL5916377 | — | k_off | = | - | s-1 | - |
| CHEMBL5922741 | — | kon | = | - | — | - |
| CHEMBL5922741 | — | k_off | = | - | s-1 | - |
| CHEMBL5867395 | — | kon | = | - | — | - |
| CHEMBL5867395 | — | k_off | = | - | s-1 | - |
| CHEMBL5992697 | — | kon | = | - | — | - |
| CHEMBL5992697 | — | k_off | = | - | s-1 | - |
| CHEMBL5916377 | — | kon | = | - | — | - |