Assay Detail
Functional
CHEMBL615123
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Cytotoxic Activity was evaluated against 143B (TK-) tumor cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | 143B |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.58 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170758 | — | — | 1 | 9.10 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170758 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 8.8 | nM | 8.06 |