Assay Detail
Binding
CHEMBL615241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of 12-LO (12-lipoxygenase) as an inhibitor of 12(S)-HETE biosynthesis in mouse epidermal homogenates
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3225) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Antipsoriatic anthrones with modulated redox properties. 3. 10-thio-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of keratinocyte growth, 5-lipoxygenase, and the formation of 12(S)-HETE in mouse epidermis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.69 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106380 | — | — | 1 | 5.52 |
| CHEMBL107212 | — | — | 1 | 5.52 |
| CHEMBL319696 | — | — | 1 | 5.22 |
| CHEMBL104489 | — | — | 1 | 4.82 |
| CHEMBL110668 | — | — | 1 | 4.57 |
| CHEMBL320923 | — | — | 1 | 4.52 |
| CHEMBL107150 | — | — | 1 | 4.52 |
| CHEMBL104361 | — | — | 1 | 4.52 |
| CHEMBL104195 | — | — | 1 | 4.52 |
| CHEMBL106514 | — | — | 1 | 4.52 |
| CHEMBL541721 | — | — | 1 | 4.52 |
| CHEMBL106899 | — | — | 1 | 4.52 |
| CHEMBL323497 | — | — | 1 | 4.52 |
| CHEMBL105777 | — | — | 1 | 4.52 |
| CHEMBL106695 | — | — | 1 | 4.52 |
| CHEMBL324408 | — | — | 1 | 4.52 |
| CHEMBL324641 | — | — | 1 | 4.52 |
| CHEMBL323991 | — | — | 1 | 4.52 |
| CHEMBL107734 | — | — | 1 | - |
| CHEMBL105506 | — | — | 1 | - |
| CHEMBL106833 | — | — | 1 | - |
| CHEMBL324197 | — | — | 1 | - |
| CHEMBL443801 | — | — | 1 | - |
| CHEMBL321110 | — | — | 1 | - |
| CHEMBL106990 | — | — | 1 | - |
| CHEMBL321652 | — | — | 1 | - |
| CHEMBL104546 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106380 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL107212 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL319696 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL104489 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL110668 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL320923 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL107150 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL104361 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL104195 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL106514 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL541721 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL106899 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL323497 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL105777 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL106695 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL324408 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL324641 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL323991 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL107734 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL105506 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL106833 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL324197 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL443801 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL321110 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL106990 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL321652 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL104546 | — | IC50 | > | 30000.0 | nM | - |