Assay Detail
Binding
CHEMBL615242
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Inhibitory activity against conversion of [1-14C]arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxygenase
22
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(Carboxyalkyl)benzyl propargyl ethers as selective inhibitors of leukocyte-type 12-lipoxygenases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.29 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144207 | — | — | 1 | 7.46 |
| CHEMBL144564 | — | — | 1 | 7.40 |
| CHEMBL357912 | — | — | 1 | 7.30 |
| CHEMBL142250 | — | — | 1 | 7.22 |
| CHEMBL144091 | — | — | 1 | 7.00 |
| CHEMBL344557 | — | — | 2 | 6.55 |
| CHEMBL341664 | — | — | 1 | 6.50 |
| CHEMBL144581 | — | — | 1 | 6.50 |
| CHEMBL144092 | — | — | 1 | 5.70 |
| CHEMBL422311 | — | — | 1 | 5.60 |
| CHEMBL2112001 | — | — | 1 | 5.30 |
| CHEMBL359008 | — | — | 1 | 5.30 |
| CHEMBL359394 | — | — | 1 | 5.22 |
| CHEMBL144674 | — | — | 1 | 5.00 |
| CHEMBL145094 | — | — | 1 | - |
| CHEMBL147680 | — | — | 1 | - |
| CHEMBL144178 | — | — | 1 | - |
| CHEMBL143392 | — | — | 1 | - |
| CHEMBL145194 | — | — | 1 | - |
| CHEMBL144297 | — | — | 1 | - |
| CHEMBL144428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144207 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL144564 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL357912 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL142250 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL144091 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL344557 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL341664 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL144581 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL344557 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL144092 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL422311 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2112001 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL359008 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL359394 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL144674 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL147680 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL145094 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL144178 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL143392 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL144297 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL145194 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL144428 | — | IC50 | > | 10000.0 | nM | - |