Assay Detail
Binding
CHEMBL615243
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Inhibitory activity against human platelet 12-lipoxygenase (12-HLO)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3687) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.50 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92359 | — | — | 1 | 6.44 |
| CHEMBL314941 | — | — | 1 | 6.44 |
| CHEMBL89283 | — | — | 1 | 6.37 |
| CHEMBL88952 | — | — | 1 | 5.66 |
| CHEMBL92212 | — | — | 1 | 5.51 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 5.29 |
| CHEMBL316139 | — | — | 1 | 4.85 |
| CHEMBL89275 | — | — | 1 | 4.58 |
| CHEMBL91531 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92359 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL314941 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL89283 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL88952 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL92212 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL316139 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL89275 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL91531 | — | IC50 | = | 42000.0 | nM | 4.38 |