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Assay Detail

CHEMBL615249

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity towards porcine 12-lipoxygenase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Arachidonate 12-lipoxygenase (CHEMBL2381)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.
Lau CK, Bélanger PC, Scheigetz J, Dufresne C, Williams HW, Maycock AL, Guindon Y, Bach T, Dallob AL, Denis D.
J Med Chem (1989) 32 : 1190 -1197
PubMed 2542553 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.40 4.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL17815 1 4.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL17815 IC50 = 40000.0 nM 4.40