Assay Detail
Binding
CHEMBL615266
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Inhibition of 5'-inosine monophosphate dehydrogenase type II (IMPDH II)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.80 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23843 | — | — | 1 | 8.10 |
| CHEMBL23716 | — | — | 1 | 7.52 |
| CHEMBL283096 | — | — | 1 | 7.19 |
| CHEMBL23842 | — | — | 1 | 6.89 |
| CHEMBL277187 | — | — | 1 | 6.82 |
| CHEMBL23108 | — | — | 1 | 6.66 |
| CHEMBL23883 | — | — | 1 | 6.64 |
| CHEMBL23127 | — | — | 1 | 6.54 |
| CHEMBL280431 | — | — | 1 | 6.44 |
| CHEMBL23590 | — | — | 1 | 6.30 |
| CHEMBL277190 | — | — | 1 | 6.30 |
| CHEMBL281635 | — | — | 1 | 6.22 |
| CHEMBL281415 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23843 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL23716 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL283096 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL23842 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL277187 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL23108 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL23883 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL23127 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL280431 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL23590 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL277190 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL281635 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL281415 | — | IC50 | > | 1000.0 | nM | - |