Assay Detail
Binding
CHEMBL615267
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Inhibitory activity against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.45 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280793 | — | — | 1 | 8.30 |
| CHEMBL27948 | — | — | 1 | 7.75 |
| CHEMBL285813 | — | — | 1 | 7.22 |
| CHEMBL26741 | — | — | 1 | 6.82 |
| CHEMBL29927 | — | — | 1 | 6.61 |
| CHEMBL29926 | — | — | 1 | 6.40 |
| CHEMBL27011 | — | — | 1 | 6.26 |
| CHEMBL27529 | — | — | 1 | 6.13 |
| CHEMBL26258 | — | — | 1 | 6.13 |
| CHEMBL26155 | — | — | 1 | 6.09 |
| CHEMBL416020 | — | — | 1 | 5.92 |
| CHEMBL26419 | — | — | 1 | 5.78 |
| CHEMBL282102 | — | — | 1 | 5.52 |
| CHEMBL27528 | — | — | 1 | 5.42 |
| CHEMBL285116 | — | — | 1 | - |
| CHEMBL27189 | — | — | 1 | - |
| CHEMBL282997 | — | — | 1 | - |
| CHEMBL283016 | — | — | 1 | - |
| CHEMBL26025 | — | — | 1 | - |
| CHEMBL29480 | — | — | 1 | - |
| CHEMBL28687 | — | — | 1 | - |
| CHEMBL26259 | — | — | 1 | - |
| CHEMBL285794 | — | — | 1 | - |
| CHEMBL27753 | — | — | 1 | - |
| CHEMBL284662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280793 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL27948 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL285813 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL26741 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL29927 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL29926 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL27011 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL27529 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL26258 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL26155 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL416020 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL26419 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL282102 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL27528 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL285116 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL27189 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL282997 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL283016 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL26025 | — | IC50 | > | 1700.0 | nM | - |
| CHEMBL29480 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL28687 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL26259 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL285794 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL27753 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL284662 | — | IC50 | > | 5000.0 | nM | - |