Assay Detail
Binding
CHEMBL615270
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Initial dissociation constant towards human 5'-methylthioadenosine phosphorylase
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
S-methyl-5'-thioadenosine phosphorylase (CHEMBL4941) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.83 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552894 | — | — | 1 | 9.24 |
| CHEMBL542449 | — | — | 1 | 8.86 |
| CHEMBL545042 | — | — | 1 | 8.44 |
| CHEMBL544806 | — | — | 1 | 8.40 |
| CHEMBL544110 | — | — | 1 | 8.36 |
| CHEMBL545740 | — | — | 1 | 8.19 |
| CHEMBL553982 | — | — | 1 | 8.19 |
| CHEMBL554965 | — | — | 1 | 8.04 |
| CHEMBL542694 | — | — | 1 | 7.70 |
| CHEMBL554642 | — | — | 1 | 7.58 |
| CHEMBL554322 | — | — | 1 | 7.58 |
| CHEMBL542452 | — | — | 1 | 7.36 |
| CHEMBL542697 | — | — | 1 | 7.25 |
| CHEMBL553375 | — | — | 1 | 7.05 |
| CHEMBL544574 | — | — | 1 | 6.87 |
| CHEMBL545273 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552894 | — | Ki | = | 0.576 | nM | 9.24 |
| CHEMBL542449 | — | Ki | = | 1.39 | nM | 8.86 |
| CHEMBL545042 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL544806 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL544110 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL545740 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL553982 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL554965 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL542694 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL554642 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL554322 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL542452 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL542697 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL553375 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL544574 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL545273 | — | Ki | = | 720.0 | nM | 6.14 |