Assay Detail
Binding
CHEMBL615322
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Inhibition of [125I]L-T3 binding to rat hepatic 3,5,3''-triiodo-L-thyronine receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of phenoxyphenyl oxamic acid derivatives related to L-thyronine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.76 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297540 | — | — | 1 | 9.77 |
| CHEMBL46882 | — | — | 1 | 9.72 |
| CHEMBL415889 | — | — | 1 | 9.60 |
| CHEMBL297183 | — | — | 1 | 9.19 |
| CHEMBL45371 | — | — | 1 | 9.04 |
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 8.96 |
| CHEMBL46814 | — | — | 1 | 8.72 |
| CHEMBL43544 | — | — | 1 | 8.72 |
| CHEMBL44667 | — | — | 1 | 8.72 |
| CHEMBL44809 | — | — | 1 | 8.70 |
| CHEMBL42961 | — | — | 1 | 8.66 |
| CHEMBL44052 | — | — | 1 | 8.27 |
| CHEMBL47137 | — | — | 1 | 8.05 |
| CHEMBL46796 | — | — | 1 | 7.85 |
| CHEMBL288972 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297540 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL46882 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL415889 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL297183 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL45371 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL1544 | LIOTHYRONINE | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL46814 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL43544 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL44667 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL44809 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL42961 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL44052 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL47137 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL46796 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL288972 | — | IC50 | = | 32.0 | nM | 7.50 |