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Assay Detail

CHEMBL615342

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of 20-HETE synthesis in human renal microsomes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Subcellular Microsome
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors.
Nakamura T, Kakinuma H, Umemiya H, Amada H, Miyata N, Taniguchi K, Bando K, Sato M.
Bioorg Med Chem Lett (2004) 14 : 333 -336
PubMed 14698153 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 8.05 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL262968 1 8.96
CHEMBL113227 1 8.96
CHEMBL115876 1 8.68
CHEMBL113275 1 8.66
CHEMBL112532 1 8.24
CHEMBL320105 1 8.11
CHEMBL113018 1 8.07
CHEMBL267865 1 8.05
CHEMBL114555 1 7.80
CHEMBL112592 1 7.35
CHEMBL114297 1 7.29
CHEMBL325429 1 6.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL262968 IC50 = 1.1 nM 8.96
CHEMBL113227 IC50 = 1.1 nM 8.96
CHEMBL115876 IC50 = 2.1 nM 8.68
CHEMBL113275 IC50 = 2.2 nM 8.66
CHEMBL112532 IC50 = 5.7 nM 8.24
CHEMBL320105 IC50 = 7.7 nM 8.11
CHEMBL113018 IC50 = 8.6 nM 8.07
CHEMBL267865 IC50 = 8.9 nM 8.05
CHEMBL114555 IC50 = 16.0 nM 7.80
CHEMBL112592 IC50 = 45.0 nM 7.35
CHEMBL114297 IC50 = 51.0 nM 7.29
CHEMBL325429 IC50 = 387.0 nM 6.41