Assay Detail
Binding
CHEMBL615343
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Inhibitory activity against 20-HETE production from arachidonic acid using human renal microsome 20-HETE synthase.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.49 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348263 | — | — | 1 | 8.64 |
| CHEMBL267865 | — | — | 1 | 8.46 |
| CHEMBL112532 | — | — | 1 | 8.24 |
| CHEMBL358880 | — | — | 1 | 8.23 |
| CHEMBL151170 | — | — | 1 | 7.64 |
| CHEMBL149750 | — | — | 1 | 7.64 |
| CHEMBL151646 | — | — | 1 | 7.57 |
| CHEMBL358216 | — | — | 1 | 7.50 |
| CHEMBL150681 | — | — | 1 | 7.42 |
| CHEMBL434317 | — | — | 1 | 7.36 |
| CHEMBL151354 | — | — | 1 | 7.01 |
| CHEMBL150146 | — | — | 1 | 6.94 |
| CHEMBL151207 | — | — | 1 | 6.84 |
| CHEMBL345544 | — | — | 1 | 6.75 |
| CHEMBL151280 | — | — | 1 | 6.09 |
| CHEMBL347302 | — | — | 1 | - |
| CHEMBL433737 | — | — | 1 | - |
| CHEMBL151096 | — | — | 1 | - |
| CHEMBL150278 | — | — | 1 | - |
| CHEMBL151974 | — | — | 1 | - |
| CHEMBL151037 | — | — | 1 | - |
| CHEMBL81948 | — | — | 1 | - |
| CHEMBL359116 | — | — | 1 | - |
| CHEMBL356594 | — | — | 1 | - |
| CHEMBL150653 | — | — | 1 | - |
| CHEMBL151449 | — | — | 1 | - |
| CHEMBL150999 | — | — | 1 | - |
| CHEMBL151038 | — | — | 1 | - |
| CHEMBL422858 | — | — | 1 | - |
| CHEMBL347303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348263 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL267865 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL112532 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL358880 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL151170 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL149750 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL151646 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL358216 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL150681 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL434317 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL151354 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL150146 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL151207 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL345544 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL151280 | — | IC50 | = | 803.0 | nM | 6.09 |
| CHEMBL358214 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL150799 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL347302 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL433737 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL151096 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL150278 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL151974 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL151037 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL81948 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL359116 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL356594 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL150653 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL151449 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL150999 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL151038 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL422858 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL347303 | — | IC50 | > | 1000.0 | nM | - |