Assay Detail
Binding
CHEMBL615353
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Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Potent inhibitors of proteasome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307387 | — | — | 1 | 8.70 |
| CHEMBL74336 | — | — | 1 | 8.22 |
| CHEMBL2114122 | — | — | 1 | 7.70 |
| CHEMBL76284 | — | — | 1 | 7.40 |
| CHEMBL73602 | — | — | 1 | 7.02 |
| CHEMBL2369773 | — | — | 1 | 6.00 |
| CHEMBL406736 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307387 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL74336 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2114122 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL76284 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL73602 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL2369773 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL406736 | — | IC50 | > | 3000.0 | nM | - |