Assay Detail
Binding
CHEMBL615354
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Inhibition of chymotrypsin-like activity of 20S proteasome
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 2 — Organism |
| Curated By | Expert |
Publication
Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.05 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67885 | — | — | 1 | 6.85 |
| CHEMBL304784 | — | — | 1 | 6.82 |
| CHEMBL66044 | — | — | 1 | 6.70 |
| CHEMBL409140 | — | — | 1 | 6.47 |
| CHEMBL70065 | — | — | 1 | 6.31 |
| CHEMBL70075 | — | — | 1 | 6.15 |
| CHEMBL303651 | — | — | 1 | 6.05 |
| CHEMBL305527 | — | — | 1 | 6.03 |
| CHEMBL303973 | — | — | 1 | 5.72 |
| CHEMBL304822 | — | — | 1 | 5.66 |
| CHEMBL67617 | — | — | 1 | 5.06 |
| CHEMBL68747 | — | — | 1 | 4.80 |
| CHEMBL303505 | — | — | 1 | - |
| CHEMBL65851 | — | — | 1 | - |
| CHEMBL420362 | — | — | 1 | - |
| CHEMBL66696 | — | — | 1 | - |
| CHEMBL431170 | — | — | 1 | - |
| CHEMBL66580 | — | — | 1 | - |
| CHEMBL307565 | — | — | 1 | - |
| CHEMBL308888 | — | — | 1 | - |
| CHEMBL305474 | — | — | 1 | - |
| CHEMBL70171 | — | — | 1 | - |
| CHEMBL69001 | — | — | 1 | - |
| CHEMBL69112 | — | — | 1 | - |
| CHEMBL303215 | — | — | 1 | - |
| CHEMBL302082 | — | — | 1 | - |
| CHEMBL69100 | — | — | 1 | - |
| CHEMBL302813 | — | — | 1 | - |
| CHEMBL66282 | — | — | 1 | - |
| CHEMBL65787 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67885 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL304784 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL66044 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL409140 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL70065 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL70075 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL303651 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL305527 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL303973 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL304822 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL67617 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL68747 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL304969 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL304751 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL303449 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL65845 | — | IC50 | > | 18000.0 | nM | - |
| CHEMBL69633 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL303505 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL65851 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL420362 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL66696 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL431170 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL66580 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL307565 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL308888 | — | IC50 | > | 18000.0 | nM | - |
| CHEMBL305474 | — | IC50 | > | 19000.0 | nM | - |
| CHEMBL70171 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL69001 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL69112 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL303215 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL302082 | — | IC50 | > | 17000.0 | nM | - |
| CHEMBL69100 | — | IC50 | > | 18000.0 | nM | - |
| CHEMBL302813 | — | IC50 | > | 18000.0 | nM | - |
| CHEMBL66282 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL65787 | — | IC50 | > | 20000.0 | nM | - |