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Assay Detail

CHEMBL615402

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]5-HT from 5-hydroxytryptamine 1 receptor of rat cortical membrane homogenates
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.
Glennon RA, Slusher RM, Lyon RA, Titeler M, McKenney JD.
J Med Chem (1986) 29 : 2375 -2380
PubMed 3783595 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.70 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL277120 1 8.30
CHEMBL9434 PHENYLPIPERAZINE 1 6.87
CHEMBL18772 QUIPAZINE 2.0 1 6.64
CHEMBL278509 1 6.58
CHEMBL30294 1 6.42
CHEMBL80691 1 6.38
CHEMBL80775 1 5.72
CHEMBL77072 1 4.98
CHEMBL78878 1 4.60
CHEMBL61236 1 4.54
CHEMBL75983 1 4.48
CHEMBL80988 1 4.35
CHEMBL80298 1 4.25
CHEMBL76495 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL277120 Ki = 5.0 nM 8.30
CHEMBL9434 PHENYLPIPERAZINE Ki = 135.0 nM 6.87
CHEMBL18772 QUIPAZINE Ki = 230.0 nM 6.64
CHEMBL278509 Ki = 265.0 nM 6.58
CHEMBL30294 Ki = 380.0 nM 6.42
CHEMBL80691 Ki = 415.0 nM 6.38
CHEMBL80775 Ki = 1900.0 nM 5.72
CHEMBL77072 Ki = 10400.0 nM 4.98
CHEMBL78878 Ki = 25000.0 nM 4.60
CHEMBL61236 Ki = 28600.0 nM 4.54
CHEMBL75983 Ki = 33000.0 nM 4.48
CHEMBL80988 Ki = 45000.0 nM 4.35
CHEMBL80298 Ki = 56000.0 nM 4.25
CHEMBL76495 Ki > 100000.0 nM -