Assay Detail
Binding
CHEMBL615407
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Inhibition constant for binding to Zn2+ form of 3-dehydroquinate synthase (DHQ) purified from Escherichia coli
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aromatic inhibitors of dehydroquinate synthase: synthesis, evaluation and implications for gallic acid biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.12 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289281 | — | — | 1 | 6.46 |
| CHEMBL285952 | — | — | 1 | 5.77 |
| CHEMBL37537 | PROTOCATECHUIC ACID | — | 1 | 4.19 |
| CHEMBL440285 | — | — | 1 | 4.05 |
| CHEMBL280998 | CATECHOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289281 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL285952 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL37537 | PROTOCATECHUIC ACID | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL440285 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL280998 | CATECHOL | Ki | = | 630000.0 | nM | - |