Assay Detail
Binding
CHEMBL615420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability of compound to inhibit the activity of 3-hydroxy-3-methylglutarylcoenzyme A(HMGR) reductase in rat liver microsomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of a monocyclic, fully functional analogue of compactin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.42 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293944 | — | — | 1 | 9.00 |
| CHEMBL60053 | — | — | 1 | 8.89 |
| CHEMBL59166 | — | — | 1 | 8.80 |
| CHEMBL58289 | — | — | 1 | 7.89 |
| CHEMBL61702 | — | — | 1 | 7.50 |
| CHEMBL434604 | — | — | 1 | - |
| CHEMBL59411 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293944 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL60053 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL59166 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL58289 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL61702 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL434604 | — | IC50 | = | 320000.0 | nM | - |
| CHEMBL59411 | — | IC50 | = | 600000.0 | nM | - |