Assay Detail
Binding
CHEMBL615425
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Binding affinity was evaluated towards 3-phosphoglycerate kinase at 37 degrees Celsius in 0.1 m NaCl pH 7.1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel bisphosphonate inhibitors of phosphoglycerate kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.88 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348433 | — | — | 1 | 6.48 |
| CHEMBL356436 | — | — | 1 | 6.16 |
| CHEMBL147415 | — | — | 1 | 4.21 |
| CHEMBL356430 | — | — | 1 | 4.21 |
| CHEMBL341829 | — | — | 1 | 4.12 |
| CHEMBL148705 | — | — | 1 | 4.10 |
| CHEMBL147362 | — | — | 1 | - |
| CHEMBL357982 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348433 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL356436 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL147415 | — | Ki | = | 61000.0 | nM | 4.21 |
| CHEMBL356430 | — | Ki | = | 61000.0 | nM | 4.21 |
| CHEMBL341829 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL148705 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL147362 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL357982 | — | Ki | = | 156000.0 | nM | - |