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Assay Detail

CHEMBL615546

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration for 50% enhancement of insulin-induced triglyceride accumulation in 3T3-L1 cells
ChEMBL ↗
40
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type 3T3-L1
Confidence 1 — Organism
Curated By Expert

Target

3T3-L1 (CHEMBL614510) ↗
Type CELL-LINE
Organism Mus musculus

Publication

Isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents.
Shinkai H, Onogi S, Tanaka M, Shibata T, Iwao M, Wakitani K, Uchida I.
J Med Chem (1998) 41 : 1927 -1933
PubMed 9599241 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 40 7.87 10.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL58132 — — 2 10.23
CHEMBL300539 — — 2 10.06
CHEMBL57855 — — 2 9.68
CHEMBL57799 — — 2 9.40
CHEMBL59132 — — 2 9.35
CHEMBL58278 — — 2 8.89
CHEMBL60927 — — 2 8.85
CHEMBL57534 — — 2 8.36
CHEMBL57508 — — 2 7.77
CHEMBL58388 — — 2 7.27
CHEMBL58885 — — 2 7.09
CHEMBL58295 — — 2 6.96
CHEMBL293526 REGLITAZAR 2.0 2 6.96
CHEMBL57181 — — 2 6.89
CHEMBL408 TROGLITAZONE 4.0 2 6.89
CHEMBL595 PIOGLITAZONE 4.0 2 6.80
CHEMBL300790 — — 2 6.64
CHEMBL59372 — — 2 6.46
CHEMBL292592 — — 2 6.43
CHEMBL294620 — — 2 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL58132 — EC50 = 0.059 nM 10.23
CHEMBL58132 — EC50 = 0.059 nM 10.23
CHEMBL300539 — EC50 = 0.087 nM 10.06
CHEMBL300539 — EC50 = 0.087 nM 10.06
CHEMBL57855 — EC50 = 0.21 nM 9.68
CHEMBL57855 — EC50 = 0.21 nM 9.68
CHEMBL57799 — EC50 = 0.4 nM 9.40
CHEMBL57799 — EC50 = 0.4 nM 9.40
CHEMBL59132 — EC50 = 0.45 nM 9.35
CHEMBL59132 — EC50 = 0.45 nM 9.35
CHEMBL58278 — EC50 = 1.3 nM 8.89
CHEMBL58278 — EC50 = 1.3 nM 8.89
CHEMBL60927 — EC50 = 1.4 nM 8.85
CHEMBL60927 — EC50 = 1.4 nM 8.85
CHEMBL57534 — EC50 = 4.4 nM 8.36
CHEMBL57534 — EC50 = 4.4 nM 8.36
CHEMBL57508 — EC50 = 17.0 nM 7.77
CHEMBL57508 — EC50 = 17.0 nM 7.77
CHEMBL58388 — EC50 = 54.0 nM 7.27
CHEMBL58388 — EC50 = 54.0 nM 7.27
CHEMBL58885 — EC50 = 81.0 nM 7.09
CHEMBL58885 — EC50 = 81.0 nM 7.09
CHEMBL293526 REGLITAZAR EC50 = 110.0 nM 6.96
CHEMBL58295 — EC50 = 110.0 nM 6.96
CHEMBL58295 — EC50 = 110.0 nM 6.96
CHEMBL293526 REGLITAZAR EC50 = 110.0 nM 6.96
CHEMBL57181 — EC50 = 130.0 nM 6.89
CHEMBL57181 — EC50 = 130.0 nM 6.89
CHEMBL408 TROGLITAZONE EC50 = 130.0 nM 6.89
CHEMBL408 TROGLITAZONE EC50 = 130.0 nM 6.89
CHEMBL595 PIOGLITAZONE EC50 = 160.0 nM 6.80
CHEMBL595 PIOGLITAZONE EC50 = 160.0 nM 6.80
CHEMBL300790 — EC50 = 230.0 nM 6.64
CHEMBL300790 — EC50 = 230.0 nM 6.64
CHEMBL59372 — EC50 = 350.0 nM 6.46
CHEMBL59372 — EC50 = 350.0 nM 6.46
CHEMBL292592 — EC50 = 370.0 nM 6.43
CHEMBL292592 — EC50 = 370.0 nM 6.43
CHEMBL294620 — EC50 = 400.0 nM 6.40
CHEMBL294620 — EC50 = 400.0 nM 6.40