Assay Detail
Binding
CHEMBL615558
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Inhibition of recombinant human adrenal 3-beta-hydroxy-delta-5-steroid dehydrogenase
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 6.49 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25516 | — | — | 1 | 8.11 |
| CHEMBL280155 | — | — | 1 | 8.00 |
| CHEMBL86832 | — | — | 1 | 7.89 |
| CHEMBL445627 | — | — | 1 | 7.72 |
| CHEMBL314069 | — | — | 1 | 7.72 |
| CHEMBL89240 | — | — | 1 | 7.24 |
| CHEMBL88494 | — | — | 1 | 7.07 |
| CHEMBL89557 | — | — | 1 | 6.89 |
| CHEMBL283123 | — | — | 1 | 6.80 |
| CHEMBL2115222 | — | — | 2 | 6.80 |
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 6.80 |
| CHEMBL421735 | — | — | 1 | 6.70 |
| CHEMBL86418 | — | — | 1 | 6.55 |
| CHEMBL327702 | — | — | 1 | 6.52 |
| CHEMBL314977 | — | — | 1 | 6.41 |
| CHEMBL283430 | — | — | 1 | 6.31 |
| CHEMBL89327 | — | — | 1 | 6.30 |
| CHEMBL87021 | — | — | 1 | 6.12 |
| CHEMBL314725 | — | — | 1 | 6.09 |
| CHEMBL87082 | — | — | 1 | 6.08 |
| CHEMBL420415 | — | — | 1 | 5.96 |
| CHEMBL328670 | — | — | 1 | 5.92 |
| CHEMBL314309 | — | — | 1 | 5.82 |
| CHEMBL88485 | — | — | 1 | 5.82 |
| CHEMBL314953 | — | — | 1 | 5.80 |
| CHEMBL277224 | — | — | 1 | 5.80 |
| CHEMBL90440 | — | — | 1 | 5.75 |
| CHEMBL88032 | — | — | 1 | 5.66 |
| CHEMBL87805 | — | — | 1 | 5.05 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25516 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL280155 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL86832 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL445627 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL314069 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL89240 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL88494 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL89557 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL283123 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2115222 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL138225 | EPRISTERIDE | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL421735 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL86418 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL327702 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2115222 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL314977 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL283430 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL89327 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL87021 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL314725 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL87082 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL420415 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL328670 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL314309 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL88485 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL314953 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL277224 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL90440 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL88032 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL87805 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL710 | FINASTERIDE | Ki | = | 11000.0 | nM | 4.96 |