Assay Detail
Binding
CHEMBL615630
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Inhibitory concentration against 5-lipoxygenase from human whole blood
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.45 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21651 | — | — | 1 | 7.16 |
| CHEMBL283559 | — | — | 1 | 6.96 |
| CHEMBL21880 | — | — | 1 | 6.66 |
| CHEMBL20599 | — | — | 1 | 6.48 |
| CHEMBL440461 | — | — | 1 | 6.47 |
| CHEMBL442334 | — | — | 1 | 6.39 |
| CHEMBL277035 | — | — | 2 | 6.30 |
| CHEMBL418742 | — | — | 1 | 6.28 |
| CHEMBL21987 | — | — | 1 | 5.35 |
| CHEMBL21242 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21651 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL283559 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL21880 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL20599 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL440461 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL442334 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL277035 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL418742 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL21987 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL21242 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL277035 | — | IC50 | > | 40000.0 | nM | - |