Assay Detail
Binding
CHEMBL616164
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Inhibition of specific [3H]OH-DPAT binding at 5-hydroxytryptamine 1A receptor in rat hippocampal membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
5-hydroxytryptamine receptor 5A (CHEMBL4655) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Derivatives of 2-arylcyclopropylamine: Synthesis and interactions with 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.82 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34653 | — | — | 1 | 8.59 |
| CHEMBL37844 | — | — | 1 | 8.31 |
| CHEMBL34652 | — | — | 1 | 7.77 |
| CHEMBL132123 | — | — | 1 | 7.24 |
| CHEMBL132019 | — | — | 1 | 6.73 |
| CHEMBL134331 | — | — | 1 | 6.62 |
| CHEMBL336124 | — | — | 1 | 6.51 |
| CHEMBL133433 | — | — | 1 | 6.42 |
| CHEMBL133935 | — | — | 1 | 6.41 |
| CHEMBL423527 | — | — | 1 | 6.37 |
| CHEMBL341373 | — | — | 1 | 6.30 |
| CHEMBL334553 | — | — | 1 | 6.13 |
| CHEMBL133020 | — | — | 1 | 6.12 |
| CHEMBL135894 | — | — | 1 | 6.00 |
| CHEMBL132580 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34653 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL37844 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL34652 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL132123 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL132019 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL134331 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL336124 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL133433 | — | Ki | = | 379.0 | nM | 6.42 |
| CHEMBL133935 | — | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL423527 | — | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL341373 | — | Ki | = | 506.0 | nM | 6.30 |
| CHEMBL334553 | — | Ki | = | 736.0 | nM | 6.13 |
| CHEMBL133020 | — | Ki | = | 752.0 | nM | 6.12 |
| CHEMBL135894 | — | Ki | = | 998.0 | nM | 6.00 |
| CHEMBL132580 | — | Ki | > | 10000.0 | nM | - |