Assay Detail
Binding
CHEMBL616430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.24 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357034 | — | — | 1 | 8.72 |
| CHEMBL1278 | NARATRIPTAN | 4.0 | 1 | 8.48 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 8.02 |
| CHEMBL905 | RIZATRIPTAN | 4.0 | 1 | 8.00 |
| CHEMBL1279 | FROVATRIPTAN | 4.0 | 1 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357034 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1278 | NARATRIPTAN | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL905 | RIZATRIPTAN | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL1279 | FROVATRIPTAN | Ki | = | 10.3 | nM | 7.99 |