Assay Detail
Binding
CHEMBL616432
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Binding affinity towards cloned human 5-hydroxytryptamine 1B receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.04 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44054 | — | — | 1 | 7.98 |
| CHEMBL300519 | — | — | 1 | 7.85 |
| CHEMBL49826 | — | — | 1 | 7.81 |
| CHEMBL45929 | — | — | 1 | 7.33 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 7.32 |
| CHEMBL300686 | — | — | 1 | 6.93 |
| CHEMBL50492 | — | — | 1 | 6.54 |
| CHEMBL297471 | — | — | 1 | 6.51 |
| CHEMBL297660 | — | — | 1 | 6.33 |
| CHEMBL49048 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44054 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL300519 | — | Ki | = | 14.2 | nM | 7.85 |
| CHEMBL49826 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL45929 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 47.9 | nM | 7.32 |
| CHEMBL300686 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL50492 | — | Ki | = | 286.0 | nM | 6.54 |
| CHEMBL297471 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL297660 | — | Ki | = | 472.0 | nM | 6.33 |
| CHEMBL49048 | — | Ki | = | 1625.0 | nM | 5.79 |