Assay Detail
Binding
CHEMBL616433
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Affinity for 5-hydroxytryptamine 1B receptor subtype
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Arylpiperazide derivatives of phenylpiperazines as a new class of potent and selective 5-HT1B receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.38 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15928 | GR-127935 | — | 1 | 9.85 |
| CHEMBL325359 | — | — | 1 | 9.30 |
| CHEMBL321818 | — | — | 1 | 9.10 |
| CHEMBL111302 | — | — | 1 | 8.89 |
| CHEMBL323986 | — | — | 1 | 8.74 |
| CHEMBL430500 | — | — | 1 | 8.70 |
| CHEMBL105970 | — | — | 1 | 8.64 |
| CHEMBL108722 | — | — | 1 | 8.10 |
| CHEMBL108645 | — | — | 1 | 8.08 |
| CHEMBL281350 | SB-224289 | — | 1 | 8.00 |
| CHEMBL106807 | — | — | 1 | 7.96 |
| CHEMBL325131 | — | — | 1 | 7.75 |
| CHEMBL110601 | — | — | 1 | 7.40 |
| CHEMBL107772 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15928 | GR-127935 | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL325359 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL321818 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL111302 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL323986 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL430500 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL105970 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL108722 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL108645 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL281350 | SB-224289 | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL106807 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL325131 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL110601 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL107772 | — | Ki | = | 150.0 | nM | 6.82 |