Assay Detail
Binding
CHEMBL616478
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Binding affinity against 5-hydroxytryptamine 2 receptor using [125I]DOI as radioligand.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.22 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137485 | — | — | 1 | 7.77 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.70 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.22 |
| CHEMBL133939 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137485 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL39 | SEROTONIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL7257 | MEBUFOTENIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL133939 | — | IC50 | = | 680.0 | nM | 6.17 |