Assay Detail
Binding
CHEMBL616488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at serotonin 5-hydroxytryptamine 2 receptor by [3H]ketanserin displacement.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.80 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 9.41 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 9.40 |
| CHEMBL303313 | — | — | 1 | 9.32 |
| CHEMBL423024 | — | — | 1 | 9.23 |
| CHEMBL12780 | — | — | 1 | 9.14 |
| CHEMBL422840 | — | — | 1 | 8.96 |
| CHEMBL423009 | — | — | 1 | 8.85 |
| CHEMBL343034 | — | — | 1 | 8.82 |
| CHEMBL144767 | — | — | 1 | 8.80 |
| CHEMBL176643 | — | — | 1 | 8.77 |
| CHEMBL422130 | — | — | 1 | 8.72 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 8.70 |
| CHEMBL366527 | — | — | 1 | 8.59 |
| CHEMBL440557 | DANITRACEN | 2.0 | 1 | 8.59 |
| CHEMBL143617 | — | — | 1 | 8.55 |
| CHEMBL95636 | TEFLUDAZINE | 2.0 | 1 | 8.51 |
| CHEMBL359031 | — | — | 1 | 8.51 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 1 | 8.51 |
| CHEMBL343444 | — | — | 1 | 8.47 |
| CHEMBL73461 | IRINDALONE | 2.0 | 1 | 8.47 |
| CHEMBL144901 | — | — | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12713 | SERTINDOLE | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL267777 | RITANSERIN | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL303313 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL423024 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL12780 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL422840 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL423009 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL343034 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL144767 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL176643 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL422130 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL51 | KETANSERIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL366527 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL440557 | DANITRACEN | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL143617 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL95636 | TEFLUDAZINE | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL359031 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL516 | CYPROHEPTADINE | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL343444 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL73461 | IRINDALONE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL144901 | — | IC50 | = | 3.6 | nM | 8.44 |