Assay Detail
Binding
CHEMBL616494
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Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [125I]DOI as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.15 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27173 | — | — | 1 | 7.85 |
| CHEMBL25800 | — | — | 1 | 7.85 |
| CHEMBL412876 | — | — | 1 | 7.20 |
| CHEMBL26427 | — | — | 1 | 7.09 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 6.89 |
| CHEMBL122860 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27173 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL25800 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL412876 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL26427 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL7257 | MEBUFOTENIN | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL122860 | — | IC50 | = | 920.0 | nM | 6.04 |