Assay Detail
Binding
CHEMBL616495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [3H]ketanserin as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.74 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25800 | — | — | 1 | 6.10 |
| CHEMBL26427 | — | — | 1 | 6.00 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 5.75 |
| CHEMBL412876 | — | — | 1 | 5.72 |
| CHEMBL27173 | — | — | 1 | 5.66 |
| CHEMBL122860 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25800 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL26427 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL7257 | MEBUFOTENIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL412876 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL27173 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL122860 | — | IC50 | = | 5900.0 | nM | 5.23 |