Assay Detail
Binding
CHEMBL616499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 2 receptor of rat anterior cortex using [3H]ketanserin as the radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.51 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274866 | — | — | 1 | 6.24 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 5.34 |
| CHEMBL18785 | RU-24969 | — | 1 | 5.27 |
| CHEMBL27403 | — | — | 1 | 5.17 |
| CHEMBL304008 | — | — | 1 | - |
| CHEMBL28178 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274866 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL39 | SEROTONIN | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL18785 | RU-24969 | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL27403 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL304008 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL28178 | — | IC50 | > | 10000.0 | nM | - |