Assay Detail
Binding
CHEMBL616500
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Compound was measured for affinity at 5-hydroxytryptamine 2 receptor in rat cortical by [3H]spiroperidol displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.82 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35057 | TIOSPIRONE | 2.0 | 1 | 8.70 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.30 |
| CHEMBL269176 | — | — | 1 | 8.00 |
| CHEMBL274334 | — | — | 1 | 8.00 |
| CHEMBL276175 | — | — | 1 | 7.70 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.52 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.89 |
| CHEMBL268267 | — | — | 1 | 6.62 |
| CHEMBL418526 | — | — | 1 | 6.60 |
| CHEMBL10875 | — | — | 1 | 6.41 |
| CHEMBL10366 | — | — | 1 | 5.92 |
| CHEMBL269458 | — | — | 1 | 5.57 |
| CHEMBL10355 | — | — | 1 | 5.51 |
| CHEMBL276378 | — | — | 1 | 5.50 |
| CHEMBL418340 | — | — | 1 | 5.09 |
| CHEMBL10546 | — | — | 1 | - |
| CHEMBL10658 | — | — | 1 | - |
| CHEMBL273505 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35057 | TIOSPIRONE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL269176 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL274334 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL276175 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL268267 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL418526 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL10875 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL10366 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL269458 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL10355 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL276378 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL418340 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL10546 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL10658 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL273505 | — | IC50 | > | 20000.0 | nM | - |