Assay Detail
Binding
CHEMBL616503
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Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.50 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 9.41 |
| CHEMBL343034 | — | — | 1 | 8.82 |
| CHEMBL331545 | — | — | 1 | 8.82 |
| CHEMBL144767 | — | — | 1 | 8.80 |
| CHEMBL422130 | — | — | 1 | 8.72 |
| CHEMBL356799 | — | — | 1 | 8.66 |
| CHEMBL144710 | — | — | 1 | 8.64 |
| CHEMBL145712 | — | — | 1 | 8.57 |
| CHEMBL143617 | — | — | 1 | 8.55 |
| CHEMBL359031 | — | — | 1 | 8.51 |
| CHEMBL144318 | — | — | 1 | 8.49 |
| CHEMBL343444 | — | — | 1 | 8.47 |
| CHEMBL144901 | — | — | 1 | 8.44 |
| CHEMBL344335 | — | — | 1 | 8.35 |
| CHEMBL144362 | — | — | 1 | 8.28 |
| CHEMBL357019 | — | — | 1 | 8.24 |
| CHEMBL141667 | — | — | 1 | 8.24 |
| CHEMBL342730 | — | — | 1 | 8.10 |
| CHEMBL355917 | — | — | 1 | 8.03 |
| CHEMBL141721 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12713 | SERTINDOLE | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL343034 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL331545 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL144767 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL422130 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL356799 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL144710 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL145712 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL143617 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL359031 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL144318 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL343444 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL144901 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL344335 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL144362 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL357019 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL141667 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL342730 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL355917 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL141721 | — | IC50 | = | 15.0 | nM | 7.82 |