Assay Detail
Binding
CHEMBL616528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human 5-hydroxytryptamine 1B receptor in L-M(tk-) cells using [3H]GR-125743 as radioligand
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.73 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79693 | — | — | 1 | 7.14 |
| CHEMBL79725 | — | — | 1 | 7.02 |
| CHEMBL79674 | — | — | 1 | 6.88 |
| CHEMBL81191 | — | — | 1 | 6.82 |
| CHEMBL79853 | — | — | 1 | 6.81 |
| CHEMBL82488 | — | — | 1 | 6.81 |
| CHEMBL81703 | — | — | 1 | 6.73 |
| CHEMBL444843 | — | — | 1 | 6.70 |
| CHEMBL1159649 | — | — | 1 | 6.70 |
| CHEMBL83732 | — | — | 1 | 6.68 |
| CHEMBL441259 | — | — | 1 | 6.68 |
| CHEMBL83617 | — | — | 1 | 6.55 |
| CHEMBL310744 | — | — | 1 | 6.51 |
| CHEMBL84171 | — | — | 1 | 6.50 |
| CHEMBL1169435 | — | — | 1 | 6.41 |
| CHEMBL311323 | — | — | 1 | - |
| CHEMBL311694 | — | — | 1 | - |
| CHEMBL311787 | — | — | 1 | - |
| CHEMBL2112307 | — | — | 1 | - |
| CHEMBL310082 | — | — | 1 | - |
| CHEMBL313452 | — | — | 1 | - |
| CHEMBL309872 | — | — | 1 | - |
| CHEMBL79561 | — | — | 1 | - |
| CHEMBL84305 | — | — | 1 | - |
| CHEMBL442974 | — | — | 1 | - |
| CHEMBL82523 | — | — | 1 | - |
| CHEMBL83112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79693 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL79725 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL79674 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL81191 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL79853 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL82488 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL81703 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL444843 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL1159649 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL83732 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL441259 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL83617 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL310744 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL84171 | — | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL1169435 | — | Ki | = | 387.0 | nM | 6.41 |
| CHEMBL311323 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL311694 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL311787 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2112307 | — | Ki | = | 19.0 | % | - |
| CHEMBL310082 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL313452 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL309872 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL79561 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL84305 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL442974 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL82523 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL83112 | — | Ki | > | 1000.0 | nM | - |