Assay Detail
Binding
CHEMBL616534
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Binding affinity towards cloned human 5-hydroxytryptamine 1B receptor
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity h5-HT1B/1D ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.09 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113950 | — | — | 1 | 8.82 |
| CHEMBL115663 | — | — | 1 | 8.82 |
| CHEMBL113994 | — | — | 1 | 8.62 |
| CHEMBL114571 | — | — | 1 | 8.52 |
| CHEMBL117397 | — | — | 1 | 8.49 |
| CHEMBL113893 | — | — | 1 | 8.42 |
| CHEMBL114780 | — | — | 1 | 8.42 |
| CHEMBL431866 | — | — | 1 | 8.38 |
| CHEMBL325175 | — | — | 1 | 8.32 |
| CHEMBL334259 | — | — | 1 | 8.24 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 8.11 |
| CHEMBL332484 | — | — | 1 | 7.96 |
| CHEMBL113868 | — | — | 1 | 7.89 |
| CHEMBL115941 | — | — | 1 | 7.85 |
| CHEMBL323603 | — | — | 1 | 7.85 |
| CHEMBL116876 | — | — | 1 | 7.77 |
| CHEMBL323666 | — | — | 1 | 7.64 |
| CHEMBL323705 | — | — | 1 | 7.41 |
| CHEMBL115415 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113950 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL115663 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL113994 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL114571 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL117397 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL113893 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL114780 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL431866 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL325175 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL334259 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL332484 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL113868 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL115941 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL323603 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL116876 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL323666 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL323705 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL115415 | — | Ki | = | 610.0 | nM | 6.21 |