Assay Detail
Binding
CHEMBL616535
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Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT trifluoroacetate as radioligand
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.20 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 9.52 |
| CHEMBL312448 | XYLOMETAZOLINE | 3.0 | 1 | 7.85 |
| CHEMBL308042 | — | — | 1 | 7.43 |
| CHEMBL73281 | — | — | 1 | 6.22 |
| CHEMBL70409 | — | — | 1 | 6.15 |
| CHEMBL307408 | — | — | 1 | 5.80 |
| CHEMBL70831 | — | — | 1 | 5.79 |
| CHEMBL72167 | — | — | 1 | 5.70 |
| CHEMBL73670 | — | — | 1 | 5.56 |
| CHEMBL72178 | — | — | 1 | 5.46 |
| CHEMBL450281 | — | — | 1 | 5.43 |
| CHEMBL303441 | — | — | 1 | 5.41 |
| CHEMBL309162 | — | — | 1 | 5.24 |
| CHEMBL308727 | — | — | 1 | 5.17 |
| CHEMBL71033 | — | — | 1 | - |
| CHEMBL72158 | — | — | 1 | - |
| CHEMBL72107 | — | — | 1 | - |
| CHEMBL73190 | — | — | 1 | - |
| CHEMBL309976 | — | — | 1 | - |
| CHEMBL71751 | — | — | 1 | - |
| CHEMBL56898 | — | — | 1 | - |
| CHEMBL73943 | — | — | 1 | - |
| CHEMBL770 | TOLAZOLINE | 4.0 | 1 | - |
| CHEMBL306940 | — | — | 1 | - |
| CHEMBL70988 | — | — | 1 | - |
| CHEMBL73429 | — | — | 1 | - |
| CHEMBL306699 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL312448 | XYLOMETAZOLINE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL308042 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL73281 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL70409 | — | Ki | = | 712.0 | nM | 6.15 |
| CHEMBL307408 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL70831 | — | Ki | = | 1630.0 | nM | 5.79 |
| CHEMBL72167 | — | Ki | = | 1995.0 | nM | 5.70 |
| CHEMBL73670 | — | Ki | = | 2780.0 | nM | 5.56 |
| CHEMBL72178 | — | Ki | = | 3480.0 | nM | 5.46 |
| CHEMBL450281 | — | Ki | = | 3735.0 | nM | 5.43 |
| CHEMBL303441 | — | Ki | = | 3865.0 | nM | 5.41 |
| CHEMBL309162 | — | Ki | = | 5785.0 | nM | 5.24 |
| CHEMBL308727 | — | Ki | = | 6830.0 | nM | 5.17 |
| CHEMBL71033 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL72158 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL72107 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL73190 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL309976 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL71751 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL56898 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL73943 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL770 | TOLAZOLINE | Ki | > | 10000.0 | nM | - |
| CHEMBL306940 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL70988 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL73429 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL306699 | — | Ki | > | 10000.0 | nM | - |