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Assay Detail

CHEMBL616539

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity to the human recombinant 5-hydroxytryptamine 1B receptor
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1B (CHEMBL1898)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-(1-Naphthyloxy)ethylamines with enhanced affinity for human 5-HT1D beta (h5-HT1B) serotonin receptors.
Ismaiel AM, Dukat M, Law H, Kamboj R, Fan E, Lee DK, Mazzocco L, Buekschkens D, Teitler M, Pierson ME, Glennon RA.
J Med Chem (1997) 40 : 4415 -4419
PubMed 9435911 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 6.28 7.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL138958 1 7.58
CHEMBL136236 1 7.18
CHEMBL139103 1 7.03
CHEMBL337539 1 7.00
CHEMBL336092 1 6.97
CHEMBL138963 1 6.92
CHEMBL138683 1 6.70
CHEMBL138136 1 6.59
CHEMBL140416 1 6.58
CHEMBL342704 1 6.54
CHEMBL2112766 1 6.50
CHEMBL140415 1 6.37
CHEMBL136470 1 6.33
CHEMBL140417 1 6.12
CHEMBL139230 1 5.95
CHEMBL136962 1 5.92
CHEMBL138907 1 5.91
CHEMBL500 PINDOLOL 4.0 2 5.58
CHEMBL334465 1 5.57
CHEMBL138509 1 5.46
CHEMBL452861 LEVOPROPRANOLOL 2.0 1 5.39
CHEMBL136311 1 5.22
CHEMBL139737 1 5.12
CHEMBL136072 1 -
CHEMBL27 PROPRANOLOL 4.0 1 -
CHEMBL139976 1 -
CHEMBL140358 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL138958 Ki = 26.0 nM 7.58
CHEMBL136236 Ki = 66.0 nM 7.18
CHEMBL139103 Ki = 94.0 nM 7.03
CHEMBL337539 Ki = 100.0 nM 7.00
CHEMBL336092 Ki = 107.0 nM 6.97
CHEMBL138963 Ki = 120.0 nM 6.92
CHEMBL138683 Ki = 200.0 nM 6.70
CHEMBL138136 Ki = 255.0 nM 6.59
CHEMBL140416 Ki = 260.0 nM 6.58
CHEMBL342704 Ki = 290.0 nM 6.54
CHEMBL2112766 Ki = 316.0 nM 6.50
CHEMBL140415 Ki = 425.0 nM 6.37
CHEMBL136470 Ki = 470.0 nM 6.33
CHEMBL140417 Ki = 750.0 nM 6.12
CHEMBL139230 Ki = 1120.0 nM 5.95
CHEMBL136962 Ki = 1205.0 nM 5.92
CHEMBL138907 Ki = 1225.0 nM 5.91
CHEMBL500 PINDOLOL Ki = 2600.0 nM 5.58
CHEMBL334465 Ki = 2675.0 nM 5.57
CHEMBL138509 Ki = 3450.0 nM 5.46
CHEMBL452861 LEVOPROPRANOLOL Ki = 4100.0 nM 5.39
CHEMBL136311 Ki = 5960.0 nM 5.22
CHEMBL139737 Ki = 7660.0 nM 5.12
CHEMBL500 PINDOLOL Ki > 10000.0 nM -
CHEMBL136072 Ki > 10000.0 nM -
CHEMBL27 PROPRANOLOL Ki > 10000.0 nM -
CHEMBL139976 Ki > 10000.0 nM -
CHEMBL140358 Ki > 10000.0 nM -